While most of its indigenous population speaks the K'iche' language, other Mayan languages spoken in the department are Ixil (Nebaj - Chajul - Cotzal area), Uspantek (Uspantán area), Sakapultek (Sacapulas area), as well as Poqomchi' and Q'ekchi in the North-Eastern part bordering with the Alta Verapaz department.
During the colonial era, San Andrés Sajcabajá functioned as a staging place, between Joyabaj and Sacapulas, on the road (camino real) connecting the Guatemalan capital (then located in Tecpán) to Chiapas.