On the other, the preservation of Roman republican culture and "virtues" was a paramount goal for Octavian, so it is ironic that his restoration of monarchy led to their complete corruption and decay and ultimately that of Latin culture in the West (Sack of Rome).
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The death of Duke Charles — the artist and goldsmith Benvenuto Cellini claimed that he fired the shot that killed him — outside the walls removed the last restraints from the army, which resulted in the sack of Rome.
After the sack of Rome, he went to Venice where he wrote his novel Portrait of Lozana: The Lusty Andalusian Woman (El retrato de la Loçana Andaluza, 1528), that continues on the lines of the novel in dialogue exemplified by Celestina.
The crisis of the culture of Catholicism was highlighted after the Protestant Reform (in 1517 Martin Luther expounded his 95 theses in Wittenberg), and the successive “sack of Rome” by the troops of Charles V in 1527, facts that rendered the papal capital more insecure and unstable, and less attractive to the artists of the Roman epoch who at the end of the 16th century were less inclined to produce a new artistic movement.
The primary source for Kircher's study of hieroglyphs was the Bembine Tablet, so named after its acquisition by Cardinal Bembo, shortly after the sack of Rome in 1527.