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In 1510 Alonso de Ojeda founded San Sebastián de Urabá, the first Spanish settlement on the mainland, but that same year its provisional ruling, Francisco Pizarro, decided to leave and moved to a site in the Gulf of Urabá and founded under the direction of Martín Fernández de Enciso to Santa María la Antigua del Darién.
The Spanish founded San Sebastian de Uraba in 1509—abandoned within the year, and in 1510 the first permanent Spanish mainland settlement in America, Santa María la Antigua del Darién.
There they founded Santa María la Antigua del Darién (c. 1509) and the now-vanished town of San Sebastian de Urabá (c. 1508-1510), the first two European settlements on the mainland of the Americas.