It is an 8-10 lane divided avenue designated as part of Circumferential Road 3 (C-3) which travels from Sergeant Rivera Street, at its north end in Balintawak, and meets Nicanor Domingo Street in the south in San Juan near the border with Santa Mesa, City of Manila.
On 1971, PCC's Laboratory High School was transferred to the new campus in Santa Mesa, Manila and the school's Katipunan Foundation, Inc. was established.
Legarda Street commences at the intersection with Lacson Avenue in the east as a continuation of Magsaysay Boulevard from Santa Mesa district.
It runs for 3.6 kilometers (2.2 miles) in a northeast-southwest direction from Nagtahan Bridge across from Santa Mesa in the north to Roxas Boulevard in Malate in the south.
It was also once the location of the headquarter of DZRJ-AM.
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When he was born at the Our Lady of Lourdes Hospital in Manila's Santa Mesa district, his sisters insisted on adding the name "Anthony" because he was born on the Feast of San Antonio de Padua.
The station is near landmarks such as the Santa Mesa Public Market, SM City Sta. Mesa, the main campus of the Polytechnic University of the Philippines (PUP), the Eulogio "Amang" Rodriguez Institute of Science and Technology (EARIST), the Sacred Heart of Jesus Catholic School and the Philippine headquarters of the Tzu Chi Foundation.