The Moselotte flows through, from upstream to downstream, the communes of La Bresse, Cornimont, Saulxures, Thiéfosse, Vagney, Saint-Amé, Le Syndicat, Dommartin-lès-Remiremont and Saint-Étienne-lès-Remiremont opposite the town of Remiremont.
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At the entry downstream of Saulxures, a lake of 9.6 hectares was set up in 1998 under the name lac de la Moselotte which hosts a leisure center.