The name "Croaker" is believed to have derived from the abundant quantity of Atlantic croaker (Micropogonias undulatus), an inshore, bottom-dwelling fish found in the Chesapeake Bay at the mouth of the York River.
An active predator with a varied diet, known prey of the great hammerhead include invertebrates such as crabs, lobsters, squid, and octopus, bony fishes such as tarpon, sardines, sea catfishes, toadfish, porgies, grunts, jacks, croakers, groupers, flatfishes, boxfishes, and porcupine fishes, and smaller sharks such as smoothhounds.