Seedco's headquarters are located in New York City and the organization does work in Alabama, Arkansas, Colorado, Florida, Georgia, Louisiana, Maryland, Massachusetts, Mississippi, New Jersey, New York, Tennessee, Texas, and Washington, D.C. Seedco also invests in low-income communities in many areas of the country through its subsidiary, Seedco Financial, to create jobs and support small business owners.
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Following the September 11 attacks in Lower Manhattan, Seedco was asked by the Ford Foundation, the New York Times Foundation, and others to implement a disaster-recovery initiative for small businesses and their workers.