He has published extensively on topics related to Islamic history and culture, with a focus on Islamic philosophy, Sufism, Twelver and Ismaili Shiism, and Arabic, Persian, and South Asian literatures.
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Shafique Virani has pursued several volunteer initiatives outside of his academic career, including founding a summer camp for Syrian youth in the Khawabi Mountains of Syria and participating in the Madrasa Resource Centre, an East African charity.