Little Shamokin Creek is a tributary of Shamokin Creek and a sub-tributary of the Susquehanna River in Northumberland County, Pennsylvania, in the United States.
The rail line runs east from Sunbury, then turns south through Paxinos and Weigh Scales to Shamokin, where it turns east again, always along or near Shamokin Creek and roughly following the route of Pennsylvania Route 61.
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