The gang maintained an uneasy truce with the other rival gangs, until 1923, when a brief gang war broke out between the Sheldon Gang and the Southside O'Donnells until O'Donnell leader Edward O'Donnell was forced to leave Chicago after being severely wounded, by Frank McErlane, during a drive-by shooting on September 25, 1925.
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In the closing days of Prohibition and with the emergence of Charles Luciano's National Crime Syndicate the Sheldon Gang, like most of the remaining bootlegging gangs, were absorbed into the syndicate by 1932.
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By 1925, rival gang boss Spike O'Donnell had reinforced his gang and once again instigated a war with the Saltis-McErlane mob, who also found themselves in conflict with the Sheldon Gang as well.