Lisa Shepperson (born 1975), Republican member of the Wyoming House of Representatives, representing the 58th district since 2007
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Sir Ernest Shepperson, 1st Baronet (1874–1949), Conservative Party politician in the United Kingdom
These include: Janet Shepperson, James Simmons, Robert Greacen, Padraic Fiacc, Michael Fanning, Des O’Grady, John Liddy, Jean O’Brien, Niall McGrath, Fred Johnston, Maurice Harmon, Gerry McDonnell, Hugh McFadden, Jack Holland, Todd Swift, Patrick Chapman, Jan Oskar Hansen and Adam Rudden.