George Zucco played Professor Moriarty in The Adventures of Sherlock Holmes (1939), while Henry Daniell would portray him in the subsequent Holmes film The Woman in Green (1945).
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The plot is an original story not based on any of Sir Arthur Conan Doyle's Holmes tales, though it bears some similarity to "The Bruce-Partington Plans." Oscar Homolka was originally cast as Holmes's elder brother Mycroft, but for family reasons he refused and Mycroft's character was replaced by "Mr. Ahrens" played by Holmes Herbert.
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