Notable people from Elkhorn Grove include early Colorado state senator and mine owner Henry Neikirk, who was born there and attended the nearby Mount Carroll Seminary (later known as Shimer College) before heading west to make his fortune.
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On November 2, 2012, ground was broken for the Frances Wood Shimer Memorial Arboretum, named after Shimer College founder and first president Frances Shimer, who planted thousands of trees around the campus.
William Parker McKee (1862–1933), chief executive of the Frances Shimer Academy, subsequently Shimer College