He trained with his father, becoming a member of the Utrecht guild of painters in 1624, and studied under Jan van Bijlert in Utrecht and with Simon Vouet in Paris.
Loreto's main monuments occupy the four sides of the piazza: the college of the Jesuits, the Palazzo Comunale (formerly the Palazzo Apostolico), designed by Bramante, with an art gallery with works of Lorenzo Lotto, Vouet and Annibale Carracci as well as a collection of maiolica, and the Shrine of the Holy House (Santuario della Santa Casa).
The seminary's oratory or chapel was built between 1683 and 1689, with interior decoration by Jacques Stella, Nicolas Poussin and Simon Vouet, and it was this chapel that operated secretly as a parish church for the area during the Revolutionary era when the area's actual parish church of Saint-Sulpice was shut down.
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He was destined for the medical profession, and well educated in Latin and Greek; but, having a natural propensity for the fine arts, he would not apply to his intended vocation, and was allowed to learn the rudiments of design under Perrier and Vouet.
Musée Vivenel holds his only surviving work, an Adoration of the Shepherds, rediscovered by that museum's curator Éric Blanchegorge - this painting inspired a work by Simon Vouet, later engraved by François Perrier.
Among the French painters who blended Italian mannerism with a love of genre scenes were Georges de La Tour, Simon Vouet, and the Le Nain brothers.
Nicolas Chaperon (Châteaudun, bapt. 19 October 1612 — Lyon 1656) was a French painter, draughtsman and engraver, a student in Paris of Simon Vouet whose style he adopted before he was further matured by his stay in Rome (1642–51) in the studio of Nicolas Poussin.
In the first chapel is a painting by Marten de Vos(1555), to the right is an Assumption by Antonio della Cornia, on the left, a Birth of the Virgin (1620) by Simon Vouet.