In a letter to the Lancet in 1993, psychiatrists David and Wessely contested the WHO classification of CFS under diseases of the nervous system, arguing that it was a form of neurasthenia to be classified as a psychiatric condition.
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In 2002, The Guardian reported on the conflict over the nature of chronic fatigue syndrome/myalgic encephalomyelitis, and whether there is an ongoing pathological process in the illness, contrasting advocates of a biological basis, such as Professors Hooper, Kenny de Meirleir and Anthony Komaroff, with advocates of a psychosocial basis, such as Professor Simon Wessely.