Frederick Louis was a son of Prince Frederick William of Hohenzollern-Hechingen (1663-1735), and his wife Countess Maria Ludovica Leopoldine of Sinzendorf (1666-1709).
The duke received important noblemen here, such as Johan von Sinzendorf und Pottendorf (1739-1813) and Joseph de Ferraris.
He came from the Sinzendorf noble family and married Countess Marie Philippine von Althann.
Philipp Ludwig Wenzel von Sinzendorf (1671–1742), Austrian diplomat and Court Chancellor (Obersthofkanzler)
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Prosper Anton Josef von Sinzendorf (1700–1756), Austrian noble man and courtier, Counsellor and Chamberlain