Siphofaneni is a town in the Lubombo Region of central Swaziland 45 kilometres from Manzini and 20 kilometres from Big Bend, a major sugarcane-producing town on the main highway leading to Durban.
In Swaziland, the river, there called the Great Usutu or Lusutfu, flows through the towns of Bhunya, Loyengo, Siphofaneni, and Big Bend.