As a music venue, Skrappy's saw the rise of many Tucson native bands such as The Bled, Versus the Mirror, Blues, The American Black Lung, Line of Fire, The Mean Reds, Beyond the Citadel of Coup de Grace and many others.
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In addition to hosting national bands (such as Botch, Fall Out Boy, Give Up the Ghost), a wide variety of local Tucson artists and small bands have played nearly nightly since its inception.