Since the development of the Marcellus Shale in the Appalachian region, Southpointe has also become home to many natural gas producers, including Range Resources, and other service companies related to the industry.
The township contains the Southpointe suburban business park; companies based there include Ansys, Consol Energy, Millcraft Industries and Mylan.
It was played for the first time in September 2010 at Southpointe Golf Club in Canonsburg, Pennsylvania, a suburb of Pittsburgh.