Early electrophysiological studies demonstrated the chemical nature of transmission at this synapse by making simultaneous intracellular recording from the presynaptic and postsynaptic terminals in vitro (Theodore Holmes Bullock and Hagiwara (1957), Hagiwara and Ichiji Tasaki (1958), Takeuchi and Takeuchi (1962).
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The calcium hypothesis for synaptic transmission was directly demonstrated in this synapse by showing that at the equilibrium potential for calcium, no transmitter is released (Bernard Katz and R. Miledi 1967).
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The squid giant synapse (Fig 1) was first recognized by John Zachary Young in 1939.
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