Although Louisville started the 2007 season as #10 in the AP Poll and returned the majority of the 2007 Orange Bowl champion team, including Heisman Trophy candidate Brian Brohm at quarterback, the Cards finished the season a disappointing 6–6, including a loss to Syracuse in which the Cardinals were 37 point favorites.
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It did not help that star running back Michael Bush suffered a season-ending knee injury in the opening game against Kentucky.
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