In Jonathan Strange and Mr. Norrell, a 2004 novel by British writer Susanna Clarke, the Duke's affection for the Queen's sister and their subsequent separation are mentioned, and made a premise for an important aspect of the story.
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She also features prominently in the book The Captive Queen of Scots by Jean Plaidy, in the short story "Antickes and Frets" by Susanna Clarke, in her 2006 collection The Ladies of Grace Adieu and Other Stories and The Secret Confessions of Anne Shakespeare by Arliss Ryan, and is the main character in the Jan Westcott historical/biographical fiction novel The Tower and The Dream.