He was succeeded by his younger brother, Sir Tatton Sykes, 4th Baronet (1772-1863), who had an interest in agricultural techniques and horse racing.
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Their one son, Mark Sykes (1879-1919) travelled in the Middle East and wrote Through five Turkish provinces and The Caliph's last heritage.
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In 1770 he made a fortunate marriage with Elizabeth, the daughter of William Tatton of Wythenshawe, Cheshire whose inheritance of £17,000 from her father was hugely augmented by her inheriting her brother's Cheshire estates and another £60,000 from her aunt in 1780.
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The Sykes Churches Trail is a tour of East Yorkshire churches which were built, rebuilt or restored by the Sykes family of Sledmere House in the East Riding of Yorkshire, England.