Their intersections display rigidity properties not possessed by smooth manifolds; the Arnold conjecture gives the sum of the submanifold's Betti numbers as a lower bound for the number of self intersections of a smooth Lagrangian submanifold, rather than the Euler characteristic in the smooth case.
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If the first Betti number of a connected symplectic manifold is zero, symplectic and Hamiltonian vector fields coincide, so the notions of Hamiltonian isotopy and symplectic isotopy of symplectomorphisms coincide.