IDE, which migrates at 110 kDa during gel electrophoresis under denaturing conditions, has since been shown to have additional substrates, including the signaling peptides glucagon, TGF alpha, and β-endorphin.
Fallon has made significant scientific contributions in several neuroscientific subjects, including discoveries of TGF alpha, epidermal growth factor, and the first to show large-scale stimulation adult stem cells in the injured brain using growth factors.
The term "juxtacrine" was originally introduced by Anklesaria et al. (1990) to describe a possible way of signal transduction between TGF alpha and EGFR.
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