Tamsweg lies at the junction of the Bundesstraßen (federal highways) B95 Turracher Straße from Mauterndorf to Predlitz-Turrach in Styria and the B96 Murtal Straße from Sankt Michael im Lungau and the A 10 Tauern Autobahn (European route E55) to Murau.
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It can also be reached by the terminal station of the Murtalbahn narrow gauge railway to the Austrian Southern Railway (Südbahn) at Unzmarkt-Frauenburg.