Tecalitlán is at the heart of the region where mariachi music was developed, and in fact the most famous exponent of that genre, Vargas de Tecalitlán, was founded there in the 1890s (though now resident in Mexico City).
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Comedienne/singer Cessy Casanova, whose father and brother have been guitarron players with Vargas de Tecalitlan, was born and raised here.
The most famous mariachi in Mexico is Mariachi Vargas de Tecalitlán, founded in the late 19th century in the southern Jalisco city of Tecalitlán, Jalisco, but now based in Mexico City.