The Jesuits began missionary work among the Tepehuan in 1596, establishing missions at Santiago Papasquiaro and Santa Catarina de Tepuhanes and, later, Zape.
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On November 16, 1616, a wagon train traveling to Mexico City was attacked by the Tepehuán just outside Santa Catarina de los Tepehuanes, a small village in the eastern foothills of the Sierra Madre Occidental.
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