Several of his children hold senior management positions in his companies, although he has groomed daughter Teresita Sy-Coson and his grandchildren Hailey Sy-Coson, Darcie Sy, Lance Harold Sy, Cheska Sy, M.honey Sy-B., Jane Sy, Sarita Sy, Samantha Ong-Sy and Josiah Sy as his successors.
In 2011, President Benigno Aquino III has chosen her as one member of the Association of Southeast Asian Business Advisory Council (ABAC) under the Department of Foreign Affairs (DFA).
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In 1985, she moved on to head the first SM shopping mall, SM City North EDSA, where she made her mark by expanding the company's retail empire.