From 2010 to 2013, she was a main cast member of the Showtime series The Big C.
The Big "C", a concrete block of the letter "C" overlooking the University of California, Berkeley
Big Finish Productions | Big Brother | Big Ten Conference | The Big Bang Theory | Big Dipper | Reel Big Fish | Big Ben | The Big Lebowski | Big Finish | Big Ten Network | Big Sur | big band | Big Day Out | Big Brother and the Holding Company | Big Bang | Big 12 Conference | List of Doctor Who audio plays by Big Finish | Big Brother (TV series) | Big East Conference (1979–2013) | Big Bird | Big Bend | Little Big Town | Great Big Sea | Big Star | Big Daddy Kane | Big Band | The Big Valley | Big Time Rush | Big Star (band) | Big Love |
Her television work includes the character Mia in the Showtime series The Big C, single appearances on White Collar, A Gifted Man, Made in Jersey, and a recurring role on the FX series, Damages.
He is currently a writer on the Showtime series The Big C starring Laura Linney.
Jastram belonged to the Museum Societies of both San Francisco and Oakland, Delta Sigma Chi Architectural Honor Society, National Trust for Historic Preservation, The Big "C" Society, and was a life member of the Mechanics' Institutes.
In September 2012, Todd sang as part of the 'Big C choir' at the Royal Albert Hall in the 2012 Sunflower Jam concert in aid of charities supporting cancer.