The show boasted many famous guest stars including Vincent Price, Ed Asner, Sammy Davis Jr., Andy Griffith, Richard Pryor, Lee Grant, Richard Dreyfuss, Tom Bosley, Danny Thomas, Tyne Daly, Martin Sheen, Louis Gosset, Jr., and Sugar Ray Robinson.
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Gerald Levert recorded a cover with Lil' Mo, which was used in the soundtrack for the movie The Mod Squad.
After small acting roles on TV series such as The Mod Squad, Emergency! and Cannon, Dobson won the role of Lt. Theo Kojak's young partner, Det. Bobby Crocker, on the TV series Kojak, opposite Telly Savalas, after he signed a contract with Universal Studios in 1972.
After The Mod Squad ended, Andrews continued to make guest appearances on various television series, such as Kojak, Marcus Welby, M.D., Police Story, CHiPs, and Murder, She Wrote.