"Regulators must extrapolate results not only from animal toxicity studies, typically from mice and/or rats to humans, but also from the very high doses usually used in animal experiments to the very low doses that are characteristic of human exposure. These two types of extrapolation are steeped in uncertainty," wrote Edward J. Calabrese, Professor of Toxicology at the University of Massachusetts Amherst' School of Public Health in Amherst, MA, USA.
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