In June 1801, Matthew Flinders' ship, HMS Investigator, carried two boxed Timekeepers by Earnshaw E520 and E543, at a cost of 100 Guineas each.
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The first expedition was with HMS Bounty which had ended in the infamous mutiny led by Fletcher Christian and from which Bligh returned to England only with the greatest of difficulties.
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Harrison made only four chronometers, but his work was carried on by others, and (generally London-based) chronometer houses sprang up, great names like John Arnold, Edward John Dent, Thomas Earnshaw, Charles Frodsham, Hamilton, and Robert Molyneux.