From February 1996 to May 1997 he served as a flight surgeon for NASA personnel deployed to the Yuri Gagarin Cosmonauts Training Center, Star City, Russia, followed by work in the Center for Flight Control in Korolyov, Russia, in support of the NASA Expedition 4 to the Mir Space Station.
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Marshburn served as a Flight Engineer on Expedition 34/35 to the International Space Station, launching aboard Soyuz TMA-07M on December 19, 2012, from the Baikonur Cosmodrome in Kazakhstan, along with crew members Chris Hadfield of the Canadian Space Agency and Russian cosmonaut Roman Romanenko.
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