Thomas Tyldesley was born on 3 September 1612 at Woodplumpton, the eldest of the six children of Edward Tyldesley (1582–1621) of Morleys Hall, Astley, in the parish of Leigh and his wife Elizabeth Preston of Holker Hall.
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New Hall, in the Park of Tyldesley, close to Damhouse by the Astley, Greater Manchester border, was in existence before 1422 when it belonged to Thomas Tyldesley.