The town of Upington in the Northern Cape is named after him, as was the short-lived Boer republic of Upingtonia.
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He was accused of propounding Parnellite principles and denounced by British politicians in Cape Town as a “Fenian” whose "offence is rank", and who "has been fraternising with Mynheer Van Dunk instead of sticking with John Bull".
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The principle issue that dominated Upington's short Ministry was the conflict over two tiny Boer mercenary states – Stellaland and Goshen – which had been established by Boer invaders in "British" Bechuanaland and which the British demanded were ejected.
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However his life-long health problems worsened and on 10 December 1898, Upington died in Wynberg, Cape Town, aged only 54.
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The state was named after Thomas Upington, prime minister of the Cape Colony, from whom the new state was hoping for support.