It was first made by Alexander Shulgin and is mentioned in his book TiHKAL, but was never tested by him.
In their book TiHKAL, Alexander and Ann Shulgin describe it as being "an order of magnitude less potent than LSD itself".
Richard Schultes in 1941 described Mexican Native American use in a short report documenting the use dating back to Aztec times cited in TiHKAL by Alexander Shulgin.
Individuals having published information on psychedelic psychotherapy in this period include George Greer, Ann Shulgin (TiHKAL, with Alexander Shulgin), and Myron Stolaroff (The Secret Chief, about the underground therapy done by Leo Zeff) and Athanasios Kafkalides.