He is the leading character in John Hersey's 1972 novel portraying Rome as a police state, The Conspiracy.
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In the 1951 film Quo Vadis, based on the novel, Tigellinus (played by Ralph Truman) is (unhistorically) stabbed to death by a soldier spectator at the cry of A sword from Plautius! in the Colosseum when the Roman people revolt against Nero at the end of the film.
Galba, however, appointed a replacement for Tigellinus, Cornelius Laco, and took several further steps to eliminate potential rivals (e.g., the murder of Lucius Clodius Macer in Africa Province), all of which must have made Nymphidius uneasy.
In 62 the praetor Antistius Sosianus, who had written abusive poems about Nero, was accused on a maiestas charge by Thrasea's old enemy Cossutianus Capito, who had recently been restored to the senate through the influence of his father-in-law Tigellinus.