Maniatis is also a pioneer in the biotechnology industry, having cofounded Genetics Institute, Inc. in 1980, ProScript Pharma in 1994, and Acceleron Pharma in 2004.
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In 1982 Maniatis along with Joe Sambrook and Edward Fritsch wrote Molecular Cloning: A Laboratory Manual, which has had an enormous impact on life sciences.
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Lerman's lab crew included at least one Nobel prize winner, Sidney Altman, and another, Tom Maniatis, who also became one of the leading molecular biologists of his time.