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unusual facts about Topoisomerase


Topoisomerase

The first topoisomerase, E. coli topo I, was discovered by James C. Wang.


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topoisomerase |

Levofloxacin

Like all quinolones, it functions by inhibiting the two type II topoisomerase enzymes, namely DNA gyrase and topoisomerase IV.

Nalidixic acid

Nalidixic acid and related antibiotics inhibit a subunit of DNA gyrase and topoisomerase IV and induce formation of cleavage complexes.

Topotecan

Topoisomerase-I is a nuclear enzyme that relieves torsional strain in DNA by opening single strand breaks.


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