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unusual facts about Tumor-induced osteomalacia


Tumor-induced osteomalacia

In season 2 of the USA Network series Royal Pains, Reshma Shetty (as Divya Katdare) diagnoses a storm chaser (Jamie Ray Newman) with recurring fractures to have tumor-induced osteomalacia.


ALECSAT

ALECSAT (Autologous Lymphoid Effector Cells Specific Against Tumor cells) technology is a novel method of epigenetic cancer immunotherapy being used by the company CytoVac.

Andreu Fontàs

On 16 March 2011, Fontàs was promoted to the senior team on a permanent basis after Éric Abidal was diagnosed with a tumour in his liver, thus becoming unavailable for the rest of the campaign.

Antuan Simmons

While undergoing an MRI on his back in the summer of 2000, a series of tests determined that there were tumors in his chest and near his kidneys.

Basal-cell carcinoma

The cause of the syndrome is a mutation in the PTCH1 tumor-suppressor gene at chromosome 9q22.3, which inhibits the hedgehog signaling pathway.

Ben Risinger

He was then brought up to San Diego, not as a player, but as the bullpen catcher when Mark Merila was battling a brain tumor.

Breslow's depth

Tumor depth is one of the cornerstones of the current AJCC TNM staging of malignant melanoma.

Brian Vala Nahed

Daniel Haber, Shyamala Maheswaran, and Mehmet Toner, they aim to harness this technology to genetically characterize tumor cells without needing an invasive biopsy, and determine responsiveness to targeted cancer drugs.

Cancer staging

In the TNM (Tumor, Node, Metastasis) system, clinical stage and pathologic stage are denoted by a small "c" or "p" before the stage (e.g., cT3N1M0 or pT2N0).

Charles R. Attwood

Attwood died at his home in Greenville, South Carolina, at the age of 66 from complications of a malignant brain tumor.

Cholangiocarcinoma

Cholangiocarcinoma is considered to be an incurable and rapidly lethal malignancy unless both the primary tumor and any metastases can be fully resected (removed surgically).

Christian Traeumer

Less than six months later he was boarding a plane to Berlin, Germany to play the lead role of “Simon Sachs” a terminally ill brain tumor patient who believes he is a serial killer in a past life in the adaptation of the best selling novel “Das Kind” (The Child) written by Sebastian Fitzek with a release date of October 2012 .

CUTL1

Researchers from the Wellcome Trust Sanger Institute reported that the mutation of CUX1 reduces the inhibitory effects of a biological inhibitor, PIK3IP1 (phosphoinositide-3-kinase interacting protein 1), resulted in higher activity of the growth promoting enzyme, phosphoinositide 3-kinase (PI3K) which leads to tumor progression.

David Leffell

Leffell was a member of the international team that discovered PTC1, a tumor suppressor gene that plays a critical role in the development of hereditary and sporadic basal cell cancer.

DecisionDx-UM

DecisionDx-UM assesses the gene expression profile (GEP) of a subset of genes which are differentially expressed in primary tumor cells compared to cells that have undergone transformation to a metastatic phenotype.

Denys–Drash syndrome

The cause of DDS is most commonly (96% of patients) an abnormality in the WT1 gene (Wilms tumor suppressor gene).

Diffuse myelinoclastic sclerosis

Diffuse myelinoclastic sclerosis, sometimes referred to as "Schilder's disease", is a very infrequent neurodegenerative disease that presents clinically as pseudotumoural demyelinating lesions, that make its diagnosis difficult.

DirectHit

DirectHit is a pharmacodiagnostic test used to determine the tumor sensitivity or resistance to drug regimens recommended for the treatment of breast cancer by the National Comprehensive Cancer Network.

Emilia Zoryan

Zoryan made her film debut in Falling Overnight as Chloe Webb, a young photographer who meets and develops a relationship with Elliot Carson (Parker Croft) on the day before he has surgery to remove a malignant brain tumor.

EML4-ALK positive lung cancer

EML4-ALK positive lung cancer is a medical term that refers to a primary malignant lung tumor whose cells contain a characteristic abnormal configuration of DNA wherein the echinoderm microtubule-associated protein-like 4 (EML4) gene is fused to the anaplastic lymphoma kinase (ALK) gene.

Epithelioid hemangioendothelioma

Epithelioid hemangioendothelioma (eHAE) is a rare tumor, first characterized by Sharon Weiss and Franz Enzinger that both clinically and histologically is intermediate between angiosarcoma and hemangioma.

Gelatinous drop-like corneal dystrophy

A number of mutations causing this disease have been described in the M1S1 (TACSTD2) gene encoding Tumor-associated calcium signal transducer 2, but not all patients have these mutations, suggesting involvement of other genes.

Genomic Medicine Institute

For clinicians, there are extensive opportunities for interaction with internationally renowned clinicians at the Cleveland Clinic at clinics, tumor boards and in direct patient care.

Giorgio Stassi

He has recently identified the role of certain cytokines, most importantly of IL-4, to block apoptosis in cancer cells in an autocrine fashion, i.e. the tumor cell itself provides the apoptosis-inhibitory stimulus by production of IL-4.

Granzyme

However, new evidence indicates that a multimeric complex (Granzyme B, perforin, and granulysin) can enter a cell through the mannose 6-phosphate receptor (or another receptor found in tumor cells) and is enclosed in a vesicle (a sac).

Harald zur Hausen

William B. Coley Award for Distinguished Research in Basic and Tumor Immunology in 2006 (with Ian Frazer)

Hibernia

Another occurrence is in familial Hibernian fever or TRAPS (tumor necrosis factor receptor-associated periodic syndrome), a periodic fever first described in 1982 in a family of Irish and Scottish descent, but found in all ethnic groups.

I Wish the Phone Would Ring

In addition to veteran members Jurado and Ann Curless, this was the first single released by Exposé to feature Kelly Moneymaker as a member of the group, since Gioia Bruno had departed in 1991 due to the discovery of a benign throat tumor.

James S. Economou

He is currently the Vice Chancellor for Research at the University of California, Los Angeles where he is also a surgical oncologist and tumor immunologist.

KIAA1524

Protein phosphatase 2A (PP2A) is a cellular tumor suppressor which inhibits cell proliferation and transformation of normal cells to malignant cancer cells.

Matthew Rice

CAT scans and MRIs identified a tumor on the right frontal lobe of his brain—ironically, the section from which artistic abilities are derived.

Mir-205

Micro-RNA-205 induced the expression of tumor suppressor genes IL-24 and IL-32 at both the messenger RNA and protein levels.

Montgomery Pittman

Efrem Zimbalist, Jr., lead star of 77 Sunset Strip, a detective series which aired from 1958 to 1964, recalls that his friend Pittman at forty-five became ill with "a tumor on the side of his neck that grew rapidly to grapefruit-size. He had it excised, but it left a gaping hole, which he covered with a kerchief".

Pancoast

Pancoast tumor, also called a pulmonary sulcus tumor or superior sulcus tumor, is a tumor of the pulmonary apex

Henry Pancoast (1875–1939), American radiologist after whom a type of lung tumor is named (Pancoast tumor)

Paul Janssen

2008: Professor Marc Feldmann, FMedSci, FAA, FRS and Emeritus Professor Sir Ravinder Maini, FRCP, FMedSci, FRS of The Kennedy Institute of Rheumatology, Imperial College London, received the 2008 Dr. Paul Janssen Award for their role in the discovery of tumor necrosis factor-alpha, or TNF-alpha, as an effective therapeutic target for rheumatoid arthritis and other autoimmune diseases.

PAX2

PAX2 is believed to be a target of transcriptional suppression by the tumor suppressor gene WT1.

Peter Samuelson

As a social entrepreneur, in 1982 Peter and his cousin, actress Emma Samms, were inspired by a boy battling an inoperable brain tumor, and started the Starlight Children's Foundation, building it into a charity dedicated to granting wishes for seriously ill children.

PKM2

In tumor cells, the increased rate of lactate production in the presence of oxygen is termed the Warburg effect.

Pleomorphic adenoma

Fine needle aspiration biopsy (FNA), operated in experienced hands, can determine whether the tumor is malignant in nature with sensitivity around 90%.

RANKL

This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor 6 (TRAF6), which indicated this protein may have a role in the regulation of cell apoptosis.

RAR-related orphan receptor alpha

The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene.

Sertoli-Leydig cell tumour

Recent studies have shown that many cases of Sertoli Leydig cell tumor of the ovary are caused by germline mutations in the DICER1 gene.

TDNA

Transfer DNA (or T-DNA), the transferred DNA of the tumor-inducing (Ti) plasmid of some species of bacteria such as Agrobacterium tumefaciens

The Music Never Stopped

Based on Oliver Sacks' essay The Last Hippie, the film tells the father-son relationship between Henry Sawyer (J.K. Simmons) and his son, Gabriel (Lou Taylor Pucci), who suffers from a brain tumor that prevents him from forming new memories.

Worcester Foundation for Biomedical Research

In the 1970s, WFEB scientists undertook the first systematic study of anti-tumor effects of the anti-estrogen tamoxifen led by 2003 Kettering Prize recipient V. Craig Jordan and initial studies of aromatase inhibitors by 2005 Kettering prize recipient Angela Brodie, two important classes of drugs to treat breast cancer.


see also