The portion of MD 208 between US 1 Alternate and US 1 was originally MD 206; the northern portion of the highway was originally part of MD 209 and then MD 410.
U.S. Route 1 (US 1) is the easternmost and longest of the major north–south routes of the United States Numbered Highway System, running from Key West, Florida to Fort Kent, Maine.
Maryland | University of Maryland | Bethesda, Maryland | Annapolis, Maryland | Silver Spring, Maryland | Montgomery County, Maryland | U.S. Route 66 | U.S. Route 1 | Cumberland, Maryland | Governor of Maryland | Frederick, Maryland | Maryland House of Delegates | Hagerstown, Maryland | U.S. Route 6 | U.S. Route 101 | Route 66 | Emmitsburg, Maryland | Columbia, Maryland | Westminster, Maryland | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | Laurel, Maryland | Howard County, Maryland | Havre de Grace, Maryland | California State Route 1 | University of Maryland, Baltimore | Bowie, Maryland | U.S. Route 1 in Maine |
The travel pattern of the county was from Bush River up to Churchville, into Dublin and to the Susquehanna River; there was no Route 1 until later years.