UBB+1 can be truncated by yeast ubiquitin hydrolase 1 (YUH1) and ubiquitin C-terminal hydrolase L3 UCHL3 despite of the fact that the glycine at position 76 as been substituted for a tyrosine.
Human UCH-L1 and the closely related protein UCHL3 have one of the most complicated knot structure yet discovered for a protein, with five knot crossings.
UCHL3 |