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A match-up between Tim Sylvia and Andrei Arlovski for the then-vacant UFC Heavyweight Championship was scheduled for the event, but Sylvia was pulled due to a reoccurrence of positive drug samples just a day before the event.
Future UFC Heavyweight Champion Junior dos Santos made his UFC debut at this event.
The main event between Tim Sylvia and Assuerio Silva was touted as a match to determine the next contender for the UFC Heavyweight Championship, then held by Andrei Arlovski.