Born in Umbertide, Lodovini grew up in Sansepolcro and to attend the School of Dramatic Arts in Perugia, then moved in Rome to continue her studies at the Centro Sperimentale di Cinematografia.
He has been a Visiting Artist at the Art Institute of Chicago in 1987 and 2002, and a Writer/Artist in Residence at Civitella Ranieri Center, Umbertide, Italy (1998), at the University of Pennsylvania (2002), and at Montalvo, California (2005).