Hide in Plain Sight (1980 film) is about a man whose ex-wife and children disappear into the program.
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In Plain Sight (2008–2012 television series) told the story of Inspectors Mary Shannon and Marshall Mann, two Deputy United States Marshals assigned to the USMS WitSec Program.
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Grand Theft Auto V (2013 video game) one of the protagonists Michael De Santa (formerly Townley) has been in Witness Protection since 2004 after a failed bank heist nine years prior to the game's events in North Yankton which left two of his accomplices dead and the other missing.
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Pia Rizza is the daughter of Vincent Rizza, who worked for the The Chicago Outfit, then subsequently testified against them and entered the Federal Witness Protection Program.
On February 21, 2003, Chicago Tribune columnist John Kass broke the story that Calabrese was talking to the Federal Bureau of Investigation, and noted that Calabrese had disappeared from the federal prison in Milan, Michigan, and that Calabrese's federal prison records had disappeared altogether, leading Kass to believe that Calabrese had entered the United States Federal Witness Protection Program.