Palmetto Village is located on USCB's South Campus in Bluffton.
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The larger "Hilton Head Gateway" campus is located between Bluffton and Hardeeville near Hilton Head Island.
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USC Beaufort has a branch in Bluffton, USC Union has a branch in Laurens and USC Salkehatchie has its main campus in Allendale with a branch in Walterboro.