Although widely accepted as part of the Midwest, the Cincinnati-Northern Kentucky metropolitan area is climatically and geographically located on the northern periphery of the Upland South region of the United States and is within the Bluegrass region of Ohio and Kentucky.
Knoxville and Huntsville are both centers of industry and scientific research.
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Ironton is largely transitional in its plant life, sharing traditionally northern trees like the blue spruce along with Magnolia and the occasional Needle Palm from the Upland South.