Upper Mustang, the former Lo Kingdom comprises the northern two-thirds of the district.
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Zhongba County has the TAR's southern border with most of western Nepal's Karnali and Dhaulagiri Zones with a border crossing into Mustang District leading through the former Lo Kingdom to its historic capital Lo Manthang.
In addition to trekking routes through the Lo Kingdom ("Upper Mustang") and along the Annapurna Circuit in lower Mustang, the district is famous for the springs and village of Muktinath (a popular Hindu and Buddhist pilgrimage site), apples, and Marpha brandy.