She continued to make 70 films with Vitagraph and during these years she played opposite almost all of the Vitagraph comedians, including John Bunny and his successor Hughie Mack, as well as child star Bobby Connelly.
Also at Vitagraph was a young actor, Harry Solter, who was looking for 'a young, beautiful equestrian girl' to star in a film to be produced by the Biograph Studios under the direction of D.W. Griffith.
Opened in 1915 as the Vitagraph Studio, the legendary lot later became the Warner Brothers Studios East Hollywood Annex, then home of the ABC Television Center and local affiliate KABC, finally becoming part of the Disney Corporation in 1996, which owns and operates it to this day.
During this period, J. Stuart Blackton was not only running the Vitagraph studio, but also producing, directing, writing, and even starring in his films (he played the comic strip character "Happy Hooligan" in a series of shorts).
The facility can trace its history back to around 1903, when it served as a studio for Vitagraph and Florence Turner, its first Vitagraph girl.
Interviews of former Vitagraph personnel conducted by Anthony Slide in the 1960s and 1970s revealed that his co-workers found him arrogant, bad-tempered, and difficult to work with, an image very much at odds with his genial on-screen persona.
He started in films in 1914 with Vitagraph and supported such well known stage and film actresses as Ethel Barrymore, Mabel Taliaferro, Charlotte Walker, Olga Petrova, Viola Dana, June Caprice, Edna Goodrich, and Mae West.
His film career began the year before playing Rev. Mark Stebbing in the Vitagraph film The Better Man, based on the novel by Cyrus Townsend Brady.
In the late silent era, Humphrey, with other original Vitagraph actors such as Florence Turner, Maurice Costello, and Flora Finch, was kept on the Metro-Goldwyn-Mayer payroll for expert playing of character roles.